DEVELOPMENT OF PROTOTYPE OF UNIVERSAL INFLUENZA VACCINE BASED ON LIVE ATTENUATED INFLUENZA VACCINE VIRAL VECTOR

Live attenuated influenza vaccine--a review.

Owing to the variability of influenza viruses, vaccine composition needs to be up-dated annually. As many variables can influence their efficacy, vaccines are still considered "sub-optimal". Many studies have been carried out in recent years to improve vaccines. In particular, researchers and vaccine-producing corporations have focused on developing a live vaccine. Among the candidate vaccines,...

Development of live cultural pandemic influenza vaccine Vector-Flu

Background The threat of pandemic A/H1N1 influenza remains a matter of considerable public concern. Recent influenza outbreaks underline the importance of rapid production of a reserve of vaccine sufficient for pandemic and interpandemic periods. Traditional vaccines intended for seasonal influenza do not satisfy this demand, because they are unable to induce cross-reactive antibodies to pandem...

Acceptability of intranasal live attenuated influenza vaccine, influenza knowledge and vaccine intent in The Gambia

BACKGROUND The burden of influenza is increasingly recognised in Africa. The WHO recommends introducing influenza vaccination to high-risk groups: pregnant women, children <5 years, and the elderly. The Gambia currently has no influenza vaccination policy, but the NASIMMUNE study, a clinical trial of intranasal live attenuated influenza vaccines (LAIV) in young children provided an opportunity ...

Development of an Attenuated Live Virus Vaccine against Sheep Pox

Small-particle aerosolization of live attenuated influenza vaccine virus.

To the Editor—In their recent study, Bischoff et al [1] exposed subjects to a small-particle aerosol of commercially available live attenuated influenza vaccine (LAIV; MedImmune LLC, Gai-thersburg, MD). LAIV was used as a proxy for wild-type influenza to evaluate the protection provided by N95 respirators, surgical masks, and eye protection. Although the study addresses the important question o...